Prime Minister Boris Johnson has tested positive for coronavirus.
Mr Johnson said he had developed mild symptoms over the past 24 hours, including a temperature and cough.
He is self-isolating in Downing Street but said he will “continue to lead the government’s response via video-conference as we fight this virus”.
Following Mr Johnson’s announcement, Health Secretary Matt Hancock also said he had tested positive for the virus.
Mr Hancock said his symptoms were also mild and he was working from home and self-isolating.
Mr Johnson was last seen on Thursday night, clapping outside No 10 as part of a nationwide gesture to thank NHS staff and carers.
He is thought to be the first world leader to announce they have the virus.
In a video on his Twitter account, Mr Johnson, 55, said: “I’m working from home and self-isolating and that’s entirely the right thing to do.
“But, be in no doubt that I can continue thanks to the wizardry of modern technology to communicate with all my top team to lead the national fight-back against coronavirus.
“I want to thank everybody involved and, of course, our amazing NHS staff.”
Over the last 24 hours I have developed mild symptoms and tested positive for coronavirus.
I am now self-isolating, but I will continue to lead the government’s response via video-conference as we fight this virus.
Together we will beat this. #StayHomeSaveLives pic.twitter.com/9Te6aFP0Ri— Boris Johnson #StayHomeSaveLives (@BorisJohnson) March 27, 2020
“So thank you to everybody who’s doing what I’m doing, working from home to stop the spread of the virus from household to household,” he added.
“That’s the way we’re going to win.”
Mr Johnson was tested at No 10 by NHS staff, on the personal advice of England’s chief medical officer, Prof Chris Whitty, Downing Street said.
He remains in charge of the government’s handling of the crisis and is understood to have chaired a phone call on Friday morning.
Earlier this week the prime minister’s spokesman said if Mr Johnson was unwell and unable to work, Foreign Secretary Dominic Raab, as the first secretary of state, would stand in.
